Publication, Presentation
Publication
| Year | Category | Literature |
|---|---|---|
| 2023 | Review | Rajavel Elango (2023): Tolerable Upper Intake Level for Individual Amino Acids in Humans: A Narrative Review of Recent Clinical Studies, Advances in Nutrition 14, 885–894. DOI.org/10.1016/j.advnut.2023.04.004 |
| 2022 | Clinical study | Naoki Miura, Koji Morishita, Takamasa Yasuda, Saori Akiduki and Hideki Matsumoto (2022): Subchronic tolerance trials of graded oral supplementation with ornithine hydrochloride or citrulline in healthy adults. Amino acids, 1-13. DOI: 10.1007/s00726-022-03227-4 |
| 2021 | Clinical study | Naoki Miura, Hideki Matsumoto, Luc Cynober, Patrick J. Stover, Rajavel Elango, Motoni Kadowaki, Dennis M. Bier and Miro Smriga (2021): Subchronic Tolerance Trials of Graded Oral Supplementation with Phenylalanine or Serine in Healthy Adults. Nutrients, 13, 1976. DOI: 10.3390/nu13061976 |
| Review | François Blachier, Anne Blais, Rajavel Elango, Kuniaki Saito, Yoshiharu Shimomura, Motoni Kadowaki, Hideki Matsumoto (2021): Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies. Amino acids, 53, 1313-1328. DOI: 10.1007/s00726-021-03054-z | |
| 2020 | Clinical study | Mary E Gheller, Francoise Vermeylen, Michal K Handzlik, Brandon J Gheller, Erica Bender, Christian Metallo, Tolunay B Aydemir, Miro Smriga, Anna E Thalacker-Mercer (2020): Tolerance to graded dosages of histidine supplementation in healthy human adults. Am. J. Clin. Nutr., 112, 1358–1367. DOI: 10.1093/ajcn/nqaa210 |
| Review | Luc Cynober, Dennis M Bier, Patrick Stover, Motoni Kadowaki, Sidney M Morris, Jr, Rajavel Elango, Miro Smriga (2020): Proposals for Upper Limits of Safe Intake for Methionine, Histidine, and Lysine in Healthy Humans. J. Nutr., 150, 2606S–2608S. DOI: 10.1093/jn/nxaa231 | |
| 2019 | Nonclinical study | Saori Akiduki, Yoko Kawada, Fumiko Watanabe, Toshikazu Kamiya, Koji Morishita (2019): Twenty-eight-day oral toxicity study of L-hydroxyproline in rats with 14-day post-treatment observation period. Fundam. Toxicol. Sci., 6, 65-74. DOI: 10.2131/fts.6.65 |
| Review | Kohsuke Hayamizu, Ikuyo Oshima, Zesoku Fukuda, Yui Kuramochi, Yuki Nagai, Nobuo Izumo, Makoto Nakano (2019): Safety assessment of L-lysine oral intake: a systematic review. Amino acids, 51, 647-659. DOI: 10.1007/s00726-019-02697-3 | |
| 2018 | Nonclinical study | Yusuke Shibui, Hideki Matsumoto, Yoko Masuzawa, Takumi Ohishi, Tsutomu Fukuwatari, Katsumi Shibata, Ryosei Sakai (2018): Thirteen week toxicity study of dietary l-tryptophan in rats with a recovery period of 5 weeks. J. Appl. Toxicol., 38, 552-563. DOI: 10.1002/jat.3562 |
| Clinical study | Catherine J. McNeal, Cynthia J. Meininger, Colin D. Wilborn, Carmen D. Tekwe & Guoyao Wu (2018): Safety of dietary supplementation with arginine in adult humans. Amino Acids, 50, 1215–1229. DOI: 10.1007/s00726-018-2594-7 | |
| 2017 | Nonclinical study | Yusuke Shibui, Ryosei Sakai, Yasuhiro Manabe, Takeshi Masuyama (2017): Comparison of L-cysteine and D-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration. J Toxicol. Pathol., 30, 217-229. DOI: 10.1293/tox.2017-0002 |
| Masahiko Morita, Tsuyoshi Yamaguchi, Koji Morishita, Ayako Kamimura (2017): A 4-week oral gavage toxicity study of L-citrulline in rats. Fundam. Toxicol. Sci., 4, 219-227. DOI: 10.2131/fts.4.219 | ||
| Nicolaas EP Deutz, Sunday Y Simbo, Gerdien C Ligthart-Melis, Luc Cynober, Miro Smriga, Mariëlle PKJ Engelen (2017): Tolerance to increased supplemented dietary intakes of methionine in healthy older adults. Am. J. Clin. Nutr., 106, 675–683. DOI: 10.3945/ajcn.117.152520 | ||
| 2016 | Nonclinical study | Yusuke Shibui, Yasuhiro Manabe, Terutaka Kodama, Akinori Gonsho (2016): 13-week repeated dose toxicity study of l-tyrosine in rats by daily oral administration. Food Chem. Toxicol., 87, 55-64. DOI: 10.1016/j.fct.2015.11.017 |
| Review | Luc Cynober, Dennis M Bier, Motoni Kadowaki, Sidney M Morris, Jr., Rajavel Elango, Miro Smriga (2016): Proposals for Upper Limits of Safe Intake for Arginine and Tryptophan in Young Adults and an Upper Limit of Safe Intake for Leucine in the Elderly. J. Nutr., 146, 2652S–2654S. DOI: 10.3945/jn.115.228478 | |
| 2015 | Nonclinical study | Keigi Chin, Sakino Toue, Yasuko Kawamata, Akiko Watanabe, Tadashi Miwa, Miro Smriga, Ryosei Sakai (2015): A 4-week toxicity study of methionine in male rats. Int. J. Toxicol., 34, 233-41. DOI: 10.1177/1091581815583678. |
| 2014 | Nonclinical study | Yusuke Shibui, Tadashi Miwa, Terutaka Kodama, Akinori Gonsho (2014): 28-Day dietary toxicity study of L-phenylalanine in rats. Fundam. Toxicol. Sci., 1, 29-38. DOI: 10.2131/fts.1.29 |
| Mami Aoki, Shigeru Ishida, Hideki Fukuzumi, Koji Morishita (2014): A 13-week feeding toxicity study of L-threonine in rats with a recovery period of 5 weeks. Fundam. Toxicol. Sci., 1, 49-62. DOI: 10.2131/fts.1.49 | ||
| Mami Aoki, Masahiro Mochizuki, Toshiya Okamura, Kazuhisa Hatayama, Atsushi Nakamura, Koji Morishita (2014): A 4-week oral toxicity study of L-alanine in rats with a recovery period of 2 weeks. Fundam. Toxicol. Sci., 1, 63-72. DOI: 10.2131/fts.1.63 | ||
| Before 2013 |
Nonclinical study | Tsubuku, S., Hatayama, K., Mawatari, K., Smriga, M. & Kimura, T. (2004) Thirteen-week oral toxicity study of L-arginine in rats. Int. J. Toxicol. 23, 101-105. DOI: 10.1080/10915810490435622 |
| Tsubuku, S., Hatayama, K., Mawatari, K., Smriga, M. & Kimura, T. (2004) Thirteen-week oral toxicity study of L-glutamine in rats. Int. J. Toxicol. 23, 107-112. DOI: 10.1080/10915810490435677 | ||
| Tsubuku, S., Mochizuki, M., Mawatari, K., Smriga, M. & Kimura, T. (2004) Thirteen-week oral toxicity study of L-lysine hydrochloride in rats. Int. J. Toxicol. 23, 113-118. DOI: 10.1080/10915810490444415 | ||
| Tsubuku, S., Hatayama, K., Katsumata, T., Nishimura, N., Mawatari, K., Smriga, M. & Kimura, T. (2004) Thirteen-week oral toxicity study of branched-chain amino acids in rats. Int. J. Toxicol. 23, 119-126. DOI: 10.1080/10915810490444424 | ||
| Yusuke Shibui, Tadashi Miwa, Mayumi Yamashita, Keigi Chin, Terutaka Kodama (2013): A 4-week Repeated Dose Toxicity Study of Glycine in Rats by Gavage Administration. J. Toxicol. Pathol., 26, 405-12. DOI: 10.1293/tox.2013-0026 | ||
| Shigeru Ishida, Miko Sarada, Hiroshi Seki, Larry McGirr, Annette Lau, Koji Morishita (2013): Genotoxicity and subchronic oral toxicity of L-ornithine monohydrochloride. Regul. Toxicol. Pharmacol., 67, 360-71. DOI: 10.1016/j.yrtph.2013.08.015 | ||
| Clinical study | Luc Cynober, Dennis M Bier, Motoni Kadowaki, Sidney M Morris, Jr., Rajavel Elango, Miro Smriga (2012): Proposals for Upper Limits of Safe Intake for Arginine and Tryptophan in Young Adults and an Upper Limit of Safe Intake for Leucine in the Elderly. J. Nutr., 146, 2652S–2654S. DOI: 10.3945/jn.115.228478 | |
| Rajavel Elango, Karen Chapman, Mahroukh Rafii, Ronald O Ball, Paul B Pencharz (2012): Determination of the tolerable upper intake level of leucine in acute dietary studies in young men. Am. J. Clin. Nutr., 96, 759–767. DOI: 10.3945/ajcn.111.024471 | ||
| Chiaki Hiratsuka, Tsutomu Fukuwatari, Mitsue Sano, Kuniaki Saito, Satoshi Sasaki, Katsumi Shibata (2013): Supplementing Healthy Women with up to 5.0 g/d of L-Tryptophan Has No Adverse Effects. J. Nutr., 143, 859–866. DOI: 10.3945/jn.112.173823 | ||
| Review | Paul B. Pencharz, Rajavel Elango, Ronald O. Ball (2012): Determination of the Tolerable Upper Intake Level of Leucine in Adult Men. J. Nutr., 142, 2220S–2224S. DOI: 10.3945/jn.112.160259 |
Event and Regulatory Activity
| Year | Event, title |
|---|---|
| 2023 | 36th Amino Acid Seminar 35th Amino Acid Seminar Liang Huimin , Yui Kuramochi, Sumika Sato, Akihide Sumino,Hideko Sone, Kohsuke Hayamizu (2023):Safety assessment of L-ornithine oral intake: a systematic review. 17th Japanese Society for Amino Acid Sciences (Fukuoka). |
| 2022 | 34th Amino Acid Seminar 33rd Amino Acid Seminar |
| 2021 | 32nd Amino Acid Seminar 31st Amino Acid Seminar |
| 2020 | 30th Amino Acid Seminar |
| 2019 | 10th Amino Acid Assessment Workshop (Tokyo) 29th Amino Acid Seminar 28th Amino Acid Seminar Nobuyo Tsuboyama-Kasaoka (2017): Frontiers in Disaster Nutrition: Disaster Dietitian and Disaster Food Certification for Nutritional Health Care. 13th Asian Congress of Nutrition |
| 2018 | 27th Amino Acid Seminar 26th Amino Acid Seminar Horoshi Mori, Kohsuke Hayamizu, Keisuke Matsumoto, Mako Nishida, Shintato Hayano, Nobuo Izumo, Yasuo Watanabe, Makoto Nakano (2018): Safety evaluation of oral amino acid intake by systematic review: From clinical trials of L-ornithine. 12th Japanese Society for Amino Acid Sciences (Tokyo). |
| 2017 | 25th Amino Acid Seminar 24th Amino Acid Seminar Shimomura, Kato, Vander Heiden, Kimball, Kitaura, Nagamori, Shiraki (2017): Novel Functions and Uses of Amino Acids. 21st International Congress of Nutrition Ikuyo Oshima, Kohsuke Hayamizu, Zesoku Fukuda, Yui Kuramochi, Yuki Nagai, Nobuo Izumo, Yasuo Watanabe, Makoto Nakano (2017): Safety evaluation of oral amino acid intake by systematic review: From clinical trials of L-lysine. 11th Japanese Society for Amino Acid Sciences (Kyoto). |
| 2016 | 23rd Amino Acid Seminar 22nd Amino Acid Seminar |
| 2015 | 9th Amino Acid Assessment Workshop (Paris) 21st Amino Acid Seminar 20th Amino Acid Seminar Shimomura, Fukatsu (2015): Basic and Clinical Aspects of Amino Acid Sciences. 12th Asian Congress of Nutrition |
| 2014 | 19th Amino Acid Seminar 18th Amino Acid Seminar |
| 2013 | 17th Amino Acid Seminar 16th Amino Acid Seminar |
| 2012 | 15th Amino Acid Seminar 14th Amino Acid Seminar Katsumi Shibata (2012): 13th ISTRY Satellite Symposium. |
| 2011 | 8th Amino Acid Assessment Workshop (Washington, DC) 13th Amino Acid Seminar 12th Amino Acid Seminar |
| 2010 | 11th Amino Acid Seminar 10th Amino Acid Seminar |
| 2009 | 9th Amino Acid Seminar 8th Amino Acid Seminar |
| 2008 | 7th Amino Acid Seminar 6th Amino Acid Seminar |
| 2007 | 7th Amino Acid Assessment Workshop (Tokyo) 5th Amino Acid Seminar 4th Amino Acid Seminar |
| 2006 | 6th Amino Acid Assessment Workshop (Budapest) 3rd Amino Acid Seminar 2nd Amino Acid Seminar |
| 2005 | 5th Amino Acid Assessment Workshop (Los Angeles) 1st Amino Acid Seminar |
| 2004 | 4th Amino Acid Assessment Workshop (Kobe) |
| 2003 | 3rd Amino Acid Assessment Workshop (Nice, France) |
| 2002 | 2nd Amino Acid Assessment Workshop (Hawaii) |
| 2001 | 1st Amino Acid Assessment Workshop (Tokyo) |