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8th AAAW November 10-11, 2011, Washington, DC

Thu, 2011-11-10-Fri, 2011-11-11
Washington DC
The 8th International Amino Acid Science Workshop (AAAW) was held at the Ritz-Carlton Hotel Georgetown (Washington, DC, USA) on November 10th and 11th, 2011.
65 industry, academia and government experts from 11 countries attended the meeting.
The purpose of this workshop is to establish a framework for evaluating and predicting the results of various amounts of leucine and tryptophan taken by humans under various conditions. The dialogue between experts in the fields of molecular biology, toxicology, regulation and policy can be continued.
In the morning session on the first day, we co-sponsored the International Life Science Research Foundation (ILSI RF) and focused on the ILSI RF approach aimed at establishing the upper limit of nutrients.
Four speakers explained the latest approach aimed at establishing upper limits for impurities and nutrients.

The safety of leucine and tryptophan was the theme for the other sessions on day 1 and the session on day 2.
Focusing on the results of the research project on these two amino acids supported by ICAAS, we focused on how to use the data to determine the upper limit of the safe intake range.
Lead speakers Dr. Paul Pencharz (Children’s Hospital in Toronto, Canada) and Hissunori Kato (University of Tokyo) presented findings from rodent and human studies on leucine.
In an acute study conducted by Dr. Pencharz’s group, the first-ever direct estimation of the safe range of leucine in humans and taking 550 m / kg-1 • d-1 or> 39 g / day may pose a health risk Raised the recognition.
In the tryptophan session, review of literature was conducted mainly by Dr. Ball (University of Alberta, Canada) and Dr. Fernstrom (University of Pittsburgh, USA).
The speaker suggested that the upper limit of tryptophan catabolism could be a marker for intake, and that increasing intake may increase the risk of side effects.
Data on the upper limit of tryptophan oxidation do not appear to be published yet.
Taking into account various health benefits, a normal dose of 5-8 g / day (70-100 mg / kg / day) gives a maximum of 15 grams / day (200 mg / kg / day for a 70 kg individual) I used tryptophan supplements.
The effective period obtained from the efficacy test is 10-28 days (longer effects may be obtained). There are currently no or no side effects associated with this.
According to a lecture by Dr. Shibata (Shiga Prefectural University), provisional NOAEL (non-toxic dose) ≥ 2,000 mg / kg (body weight) and LOAEL (minimum adverse effect concentration) 5,000 mg / kg (body weight) in rodent experiments The ratio of urinary excretion of anthranilic acid / kynurenic acid is likely to be an index of an alternative tolerance limit (breakpoint) that is optimal for predicting the allowable upper limit intake (UL) of tryptophan. The This research is currently being conducted in human subjects with healthy women as subjects.
The 8th AAAW proceedings will be published in 2012 as an appendix to the Journal of Nutrition.
ICAAS members hope the proceedings will be useful to both researchers and government agencies working on amino acid UL.
ICAAS operates on the premise of providing scientific evidence to support regulatory activities in this area.
Research findings reported during the workshop will materialize this, and discussions regarding the upper limit of allowable amino acid intake will change in the future.

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