非臨床試験

アミノ酸 動物種 論文
L-グルタミン酸 CD-1 mouse Glutamic Acid: Advances in Biochemistry and Physiology, ed. by Filer LJ, et al., Raven Press, NY (1979):231-253
“In utero and dietary administration of monosodium L-glutamate to mice: Reproductive performance and development in a multigeneration study”
Anantharaman K
L-グルタミン酸 SD rat
(6 wks age)
Int J Toxicol (2004), 23(2):107-112
“Thirteen-week oral toxicity study of L-glutamine in rats.”
Tsubuku S, Hatayama K, et al.
L-アルギニン SD rat
(6 wks age)
Int J Toxicol (2004), 23(2):101-105
“Thirteen-week oral toxicity study of L-arginine in rats”
Tsubuku S, Hatayama K, et al.
Pig
(30 days age)
Amino Acids (2015), 47(5):925-936
“Safety of long-term dietary supplementation with L-arginine in pigs”
Hu S, Li X, et al.
SD rat
(6 wks age)
Amino Acids (2015), 47(9):1909-1920
“Safety of long‑term dietary supplementation with L‑arginine in rats”
Yang Y, Wu Z, et al.
L-バリン SD rat
(6 wks age)
Int J Toxicol (2004), 23(2):119-126
“Thirteen-week oral toxicity study of branched-chain amino acids in rats”
Tsubuku S, Hatayama K, et al.
L-ロイシン SD rat
(6 wks age)
L-イソロイシン SD rat
(6 wks age)
L-リジン SD rat
(6 wks age)
Int J Toxicol (2004), 23(2):113-118
“Thirteen-week oral toxicity study of L-lysine hydrochloride in rats”
Tsubuku S, Mochizuki M, et al.
L-アラニン SD rat
(6 wks age)
Fund Toxicol Sci (2014), 1(2):63-72
“A 4-week oral toxicity study of L-alanine in rats with a recovery period of 2 weeks”
Aoki M, Mochizuki M, et al.
DL-アラニン Wistar rat Toxicol Appl Pharm (1976), 37(7):491-497
“Alanine: A toxicity study”
Chow FC, Dysart MI, et al.
L-アスパラギン Fisher rat
(7 wks age)
Food Chem Toxicol (2008), 46(7):2568-2572
“A 90-day toxicity study of L-asparagine, a food additive, in F344 rats”
Yokohira M, Hosokawa K, et al.
L-アスパラギン酸 Fisher rat
(7 wks age)
Food Chem Toxicol (2008), 46(8):2789-2795
“Toxic effects of L-aspartic acid at high dose levels on kidneys and salivary glands in Fischer 344 rats detected in a 90-day feeding study”
Tada Y, Yano N, et al.
L-システイン SD rat
(6 wks age)
J Toxicol Pathol (2017), 30(3):217-229
“Comparisons of L-cysteine and D-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration”
Shibui Y, Sakai R, et al.
D-システイン SD rat
(6 wks age)
L-シスチン Wister rat
(5 wks age)
[Japanese]
Oyo Yakuri (1978), 15(2):199-221
“Acute and subacute toxicity of cystenosine®, inosine and cystine in rats”
Kawai Y, Okai M, et al.
L-グリシン SD rat
(6 wks age)
J Toxicol Pathol (2013), 26(4) 405–412, 2013
“A 4-week repeated dose toxicity study of glycine in rats by gavage administration”
Shibui Y, Miwa T, et al.
L-ヒスチジン Fisher rat
(6 wks age)
[Japanese]
Bull Natl Ins Health Sci (1994), 112:57-63
“13-week subchronic toxicity study of L-histidine monohydrochloride in F344 rats”
Ikezaki S, Nishikawa A, et al.
L-メチオニン Fisher rat ♂
(5 wks age)
Int J Toxicol (2015), 34(3):233-241
“A 4-week toxicity study of methionine in male rats”
Chin K, Toue S, et al.
DL-メチオニン Pig [French]
C R Seances Acad Sci D (1980) 291(6): 565-568
“Enzymatic activities in the liver, and muscle nucleic acids, in swine receiving an unbalanced diet with an exceed of methionine for 100 days”
Fau D, Delhomme B, et al.
Wistar rat
(9 wks age)
J Nutr (1988), 118(1):128-133
“Effect of ingestion of high protein excess methionine diets by rats for two years”
Fau D, Peret J, et al.
L-フェニルアラニン SD rat
(5 wks age)
Fund Toxicol Sci (2014), 1(2):29-38
“28-Day dietary toxicity study of L-phenylalanine in rats”
Shibui Y, Miwa T, et al.
L-プロリン Fisher rat
(6 wks age)
Regul Toxicol Pharmacol (2010), 58(1):114-120
“Toxicological evaluation of L-proline in a 90-day feeding study with Fischer 344 rats”
Tada Y, Yano N, et al.
L-セリン SD rat
(6 wks age)
Food Chem Toxicol (2009), 47(9):2356-2360
“A 13-week subchronic oral toxicity study of L-serine in rats”
Kaneko I, Han L, et al.
Fisher rat J Toxicol Pathol (2010), 23(1):39-47
“A 90-day feeding toxicity study of L-serine in male and female Fischer 344 rats”
Tada Y, Yano N, et al.
L-スレオニン SD rat
(6 wks age)
Fund Toxicol Sci (2014), 1(2):49-62
“A 13-week feeding toxicity study of L-threonine in rats with a recovery period of 5 weeks”
Aoki M, Ishida S, et al.
L-トリプトファン SD rat
(6 wks age)
J Appl Toxicol (2018), 38(4): 552-563
“Thirteen week toxicity study of dietary L‐tryptophan in rats with a recovery period of 5 weeks”
Shibui Y, Matsumoto H, et al.
L-チロシン SD rat
(6 wks age)
Food Chem Toxicol (2016), 87:55-64
“13-week repeated dose toxicity study of l-tyrosine in rats by daily oral administration”
Shibui Y, Manabe Y, et al.
L-オルニチン SD rat
(6 wks age)
Regul Toxicol Pharmacol (2013), 67(3):360-71
“Genotoxicity and subchronic oral toxicity of L-ornithine monohydrochloride”
Ishida S, Sarada M, et al.
L-シトルリン SD rat
(6 wks age)
Fund Toxicol Sci (2017), 4(5):219-227
“A 4-week oral gavage toxicity study of L-citrulline in rats”
Morita M, Yamaguchi T, et al.
L-ヒドロキシプロリン SD rat
(5-6 wks age)
Fund Toxicol Sci (2019), 6(3):65-74
“Twenty-eight-day oral toxicity study of L-hydroxyproline in rats with 14-day post-treatment observation period”
Akiduki S, Kawada Y, et al.

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