臨床試験

Item:
Amino acid (AA)
Reference Information for safety human study
 [L1]:  Safety assessment study  [L2] : Safety review  [L3]  Case study (short term, one dose, etc)
L-Glutamine Journal of Parenteral and enteral nutrition (2004) 28(2):65-75, Rathmacher JA, et al.  Regulatory Toxicology and Pharmacology (2008), 50(3):376-399, Shao A, et al. Nutrients (2020) 12(10):E2953, Ogden HB, et al.
L-Arginine Amino Acids (2018), 50(1):1215-1229, McNeal CJ, et al The Journal of Nutrition (2016), 146(12): 2652S-2654S, Cynober L, et al.
Regulatory Toxicology and Pharmacology (2008), 50(3):376-399, Shao A, et al.
 
L-Leucine American Journal of Clinical Nutrition (2012), 96(8):759-767, Elango R, et al. The Journal of Nutrition (2016), 146(12):2652S-2654S, Cynober L, et al.
The Journal of Nutrition (2012), 142(12):2220S-2224S, Pencharz PB, et al. 
 
Glycine
(aminoacetic acid)
Journal of Urban Living and Health Association (2006), 50(1):27-32,  Inagawa K, et al. No review report of safety & clinical trial  
L-Methionine American Journal of Clinical Nutrition (2017) 106(2):675-683, Deutz NEP, et al.  No review report of safety & clinical trial 1) Nutrition(2002), 21(2):151-156, Krupkova-Meixnerova L, et al.
2) Revista de Investigacion Clinica (2013), 65(4):323-330, Majluf-Cruz A, et al.
L-Tryptophan The Journal of Nutrition (2013), 143(6):859-866, Hiratsuka C, et al. The Journal of Nutrition (2016), 146(12): 2652S-2654S, Cynober L, et al.  
L-Lysine/HCl No clinical report on safety assessment Amino Acids (2019), 51(4):647-659, Hayamizu K, et al.  
L-Histidine American Journal of Clinical Nutrition (2020), 112(5): 1358-1367, Gheller ME, et al.  The Journal of Nutrition, Volume 150, Issue Supplement_1, October 2020, Pages 2606S–2608S, Cynober L, et al.  
L-Phenylalanine No clinical report on safety assessment No review report of safety & clinical trial Diabetes, metabolic Syndrome and Obesity (2018), 11:22-33
Journal of the International Society of Sports Nutrition (2017), 14:34, Ueda K, et al. 
L-Serine No clinical report on safety assessment in healthy volunteer

[In ASL Patients]
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2017), 18:107-111
Neurotoxicity Research (2018), 33(1):213-221

2) sited right1) original article (ASL patients)
 
L-Ornithine/HCl No clinical report on safety assessment No review report of safety & clinical trial Nutrition Research (2008), 28(11):738-743
L-Citruline No clinical report on safety assessment No review report of safety & clinical trial British Journal of Nutrition (2008), 99(4):855-862
L-Valine No clinical report on safety assessment
(Valine alone)
No review report of safety & clinical trial  
L-Iosleucine No clinical report on safety assessment
(Valine alone)
No review report of safety & clinical trial  
L-Alanine No clinical report on safety assessment
(L-Alanine alone)
No review report of safety & clinical trial  
D,L-Alanine No clinical report on safety assessment No review report of safety & clinical trial Biological Psychiatry (2006), 59(3):230-234
L-Aspartic Acid No clinical report on safety assessment No review report of safety & clinical trial Metabolism (1989), 38(2):1179-l 182
L-Asparagine No clinical report on safety assessment No review report of safety & clinical trial  
D,L-Methionine No clinical report on safety assessment No review report of safety & clinical trial  
L-Cysteine/HCl No clinical report on safety assessment No review report of safety & clinical trial  
L-Cysteine No clinical report on safety assessment No review report of safety & clinical trial Metabolism (1989), 28(12):1179-1182
L-Cystine SEIKATSU EISEI (2008), 52(4):229-236 No review report of safety & clinical trial  
L-Proline No clinical report on safety assessment No review report of safety & clinical trial  
L-Threonine No clinical report on safety assessment No review report of safety & clinical trial Clinical neuropharmacology (1991), 14(5):403-412
Acta Neurologica Scandinavica (1993), 88(5):334-338
Neurology (1996), 47(5):1220-1226
L-Tyrosine No clinical report on safety assessment No review report of safety & clinical trial Hypertension (1985), 7(4):593-596
The Lancet (1989), 334(8671):1067-1069
Aviation, Space and Environmental Medicine (1995), 66(4):313-319
Journal of Child Neurology (2008),23(6):609-13
L-Hydroxyproline No clinical report on safety assessment No clinical report on safety assessment  
      (last update: 20210201)

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