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This method (see PDF) relates to “insoluble foreign matter” for detecting water-insoluble foreign matter.
Since high-quality amino acids are soluble in the right environment, insoluble foreign matter in the sample solution indicates the degree of microbial contamination of poor quality products.
As shown in the graph below, the amount of insolubles is strongly correlated with the frequency of bacterially contaminated samples.
The fewer insoluble particles, the easier it is to eliminate products that contain bacteria.
< 10 particles (size 1 x 1 mm) standard proposed by ICAAS eliminates 80% of low quality samples. The number of bacteria is usually counted by growing the bacteria on a plate. The proposed insoluble foreign matter test is easier and faster than the bacterial count method and can be used for all major amino acids listed below.
amino acid(th) | Crystal form | CAS registration number |
---|---|---|
L-alanine | 56-41-7 | |
L-Arginine | 74-79-3 | |
L-Arginine HCl | 74-79-3 | |
L-asparagine | Monohydrate | 5794–13-8 |
L-asparagine | anhydrous | 70-47-3 |
L-Aspartic acid | 56-84-8 | |
L-cysteine HCl H2O | Monohydrate | 7048-48-6 |
L-cysteine HCl H2O | anhydrous | 5289/1/1 |
L-cystine | 56-89-3 | |
L-glutamic acid | 56-86-0 | |
L-glutamic acid | Hydrochloride | 38-15-8 |
L-glutamine | 56-85-9 | |
glycine | 56-40-6 | |
L-histidine | 71-00-1 | |
L-histidine HCl H2O | 5934-29-2 | |
L-histidine HCl H2O | 5934-29-2 | |
L-methionine | 63-68-3 | |
L-Phenylalanine | 63-91-2 | |
L-Proline | 147-85-3 | |
L-serine | 56-45-1 | |
L-threonine | 72-19-6 | |
L-tryptophan | 73-22-3 | |
L-tyrosine | 60-18-4 | |
L-Valine | 72-18-4 |